Package: dotgen 0.1.0

Xiaoran Tong

dotgen: Gene-Set Analysis via Decorrelation by Orthogonal Transformation

Decorrelates a set of summary statistics (i.e., Z-scores or P-values per SNP) via Decorrelation by Orthogonal Transformation (DOT) approach and performs gene-set analyses by combining transformed statistic values; operations are performed with algorithms that rely only on the association summary results and the linkage disequilibrium (LD). For more details on DOT and its power, see Olga (2020) <doi:10.1371/journal.pcbi.1007819>.

Authors:Olga Vsevolozhskaya [aut], Dmitri Zaykin [aut], Xiaoran Tong [aut, cre]

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dotgen.pdf |dotgen.html✨
dotgen/json (API)

Peer review:

Bug tracker:https://github.com/xiaoran831213/dotgen/issues

On CRAN:

9 exports 0.52 score 1 dependencies 2 scripts 283 downloads

Last updated 4 years agofrom:89960cae63. Checks:OK: 1 WARNING: 6. Indexed: yes.

Exports:cstdotdot_artdot_artadot_chisqdot_fisherdot_rtpdot_tpmzsc

Dependencies:mvtnorm